https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52384 Wed 28 Feb 2024 15:35:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53520 28.4 ng/mL) was independently associated with older age, use of beta-blockers, and number of MACE events within a 1 year period. In this patient cohort, elevated sST2 levels are associated with unplanned hospital admission due to MACE within 1 year, independent of the nature of the index cardiovascular admission.]]> Wed 28 Feb 2024 15:31:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52044 Wed 27 Sep 2023 10:07:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45109 n = 230 patients (mean age 65, males n = 124 (53.9%)) were treated with bevacizumab during the study period. N = 28 patients were admitted to hospital for a major cardiovascular-related event. Higher total treatment dose (p < 0.05), concomitant hypertension (p = 0.005), diabetes (p = 0.04), atrial fibrillation (p = 0.03), and lack of use of statin therapy (p = 0.03) were key contributors to hospital admission. Conclusions: Results of our study highlight the fact that patients with concomitant baseline cardiovascular disease/risk factors are at an increased risk of cardiovascular hospitalization related to bevacizumab treatment. Careful baseline cardiovascular assessment may be an essential step to minimize cardiovascular complications.]]> Wed 26 Oct 2022 13:22:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45068 Wed 26 Oct 2022 12:31:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48902 Wed 19 Apr 2023 16:30:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53423 Wed 17 Apr 2024 14:39:15 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49072 Wed 03 May 2023 16:08:08 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42651 Wed 01 Mar 2023 15:00:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52575 Tue 17 Oct 2023 15:48:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44253 Tue 11 Oct 2022 12:28:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46897 Tue 06 Dec 2022 13:41:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44090 Thu 06 Oct 2022 15:55:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53264 Mon 20 Nov 2023 12:20:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53262 Mon 20 Nov 2023 12:14:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52280 Mon 09 Oct 2023 10:02:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42207 2) during planned bariatric surgery. Compared with subcutaneous adipose tissue, visceral adipose tissue exhibited decreased complex II activity, which was restored with the reducing agent dithiothreitol (5 mM) (P < 0.01). A biotin switch assay identified that cysteine oxidative posttranslational modifications (OPTM) in complex II subunit A (succinate dehydrogenase A) were increased in visceral vs. subcutaneous fat (P < 0.05). Insulin treatment (100 nM) stimulated complex II activity in subcutaneous fat (P < 0.05). In contrast, insulin treatment of visceral fat led to a decrease in complex II activity (P < 0.01), which was restored with addition of the mitochondria-specific oxidant scavenger mito-TEMPO (10 µM). In a cohort of 10 subjects with severe obesity, surgical weight loss decreased OPTM and restored complex II activity, exclusively in the visceral depot. Mitochondrial complex II may be an unrecognized and novel mediator of insulin resistance associated with visceral adiposity. The activity of complex II is improved by weight loss, which may contribute to metabolic improvements associated with bariatric surgery.]]> Fri 26 Aug 2022 09:16:37 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48913 Fri 14 Apr 2023 18:21:40 AEST ]]>